Vol 8, No 2 (2014)

Articles
The Prognostic Value of Parathyroid Hormone for the Diagnosis of Early Postoperative Hypocalcemia after Thyroidectomy
Simakina O.V., Latkina N.V., Kim I.V., Kuznetsov N.S.

Abstract

Postoperative hypocalcemia is the most frequent complication after thyroidectomy. One goal of our study was to investigate the parathyroid hormone (PTH) as the main predictor and early postoperative hypocalcemia. The study prospectively included 135 patients who from October 2011 to May 2013 was performed thyroidectomy. According to the results according to logistic regression analysis, postoperative PTH level below 10 pg/ml was the main predictor of postoperative hypocalcemia ( p <0,001). Sensitivity, specificity, positive and negative predictive value of PTH <10 pg / ml for predicting postoperative hypocalcemia were 71%, 99%, 97% and 86%, respectively. It can be concluded that measurement of PTH after 1 hour, and / or on the following day after thyroidectomy hypocalcemia predicts with high sensitivity, specificity. And early detection of PTH allows timely appoint agents calcium and vitamin D to prevent clinical manifestations of postoperative hypoparathyroidism.
Endocrine Surgery. 2014;8(2):4-8
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Difficulties in the Diagnosis of ACTH-ectopic Tumors. Case Report
Kuznetsov N.S., Marova E.I., Latkina N.V., Lanshchakov K.V., Dobreva E.A., Krylov V.V.

Abstract

At the present time topical diagnosis of ACTH-producing neuroendocrine tumors of different localization is the most challenging problem for endocrinologists around the world. Despite the significant improvement of existing diagnostic techniques, in 9-19% localization of the source of ectopic secretion ACTH re-mains undetected throughout life. Thus even regular using of routine laboratory tests and visual methods of diag- nosis do not allow to reveal the primary tumor. This article describes a case report, that is particular by a long period of ectopic ACTH syndrome detection. However, this demonstrates the importance of inten-sive and prolonged diagnosis of primary tumor, that can significantly reduce the morbidity and mortality of these patients and improve their prognosis.
Endocrine Surgery. 2014;8(2):9-13
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Study of PTH-FNAB of the Parathyroid Glands as a Method of Topical Diagnosis in Primary Hyperparathyroidism
Kim I.V., Kuznetsov N.S., Kuznetsov S.N.

Abstract

The main difficulty of primary hyperparathyroidism in the surgical aspect, it is possible atypical location of the parathyroid glands and multiple nature of the lesion. Proposed significant number of methods for pre- operative and intraoperative for topical diagnosis in primary hyperparathyroidism and the search for new methods and continues to the present. The proposed method of topical diagnostic studies of PTH-FNAB has a high statistical parameters of sensi- tivity, specificity and predictive value. This method is needed as an additional parameter specifying, in the topical diagnosis of primary hyperparathyroidism, especially in the case of ambiguous and questionable data received basic methods of topical studies in primary hyperparathyroidism.
Endocrine Surgery. 2014;8(2):14-19
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A Late Onset of Adrenocortical Cancer Assosiated with Beckwith-Wiedemann Syndrome
Kuznetsov N.S., Latkina N.V., Kalinchenko N.Y., Selivanova L.S., Raykhman A.O.

Abstract

Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth disorder involving a predisposition to tumor development. The common features of Beckwith-Wiedemann syndrome include omphalocele, macroglos- sia and macrosomia. The increased risk for neoplasia is concentrated in the first eight years of life. However, this case presents a late onset of adrenocortical cancer assosiated with Beckwith-Wiedemann syndrome.
Endocrine Surgery. 2014;8(2):20-26
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Review article Romanchishen A.F., Vabalayte K.V. “Russian Thyroid Surgery Origin, Development in XIX - Beginning of XX Century and Present Time” (2014, №1)
Smirnova O.M.

Abstract

Endocrine Surgery. 2014;8(2):27-28
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